Of the 6,446 patients with previous IS/TIA, 4,393 (68.2%) were taking DOACs, and 1,668 (25.9%) were taking warfarin at enrollment. Thus, net clinical outcomes were also higher in stroke/TIA survivors (7.84 vs. 1.23/100 PY adjusted hazard ratio 2.25, 95% CI 1.97–2.58), major bleeding, IS, ICH, and all-cause death were more common during follow-up in patients with stroke/TIA than those without. Takeshi Yoshimoto and colleagues used a huge database of the ANAFIE Registry, where more than 33,000 NVAF patients aged ≥75 years were registered from 1,273 medical institutions throughout Japan between 20 and followed up with for 2 years.Īll of stroke/SE (3.01 vs. However, studies on the incidence of events and event risk factors in elderly patients with NVAF and previous stroke/TIA are limited. Both the risks of IS and ICH increase with increasing age. ![]() The challenge in anticoagulant therapy in secondary prevention is the balance between the benefit of preventing ischemic events and the risk of bleeding, in particular ICH. ![]() Thus, preventing subsequent ischemic stroke (IS) and intracranial hemorrhage (ICH) in AF patients with a history of stroke/TIA has become increasingly important. Prior stroke/TIA increases the stroke risk of AF patients by 2.5 times. Researchers at the National Cerebral and Cardiovascular Center in Japan found that patients aged ≥75 years with non-valvular atrial fibrillation (NVAF) and previous stroke/transient ischemic attack (TIA) more commonly had subsequent ischemic and hemorrhagic events than those without previous stroke/TIA in the prospective, multicenter, observational All Nippon AF In the Elderly (ANAFIE) Registry.ĪF is an independent risk factor for stroke, systemic embolism (SE) and all-cause death.
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